POC Betahydroxybutyrate

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Good morning, All!

We have an endocrine clinic that would like a Point of Care test specifically for Betahydroxybutyrate. We are finding it difficult to find a waived test kit that does not take an extended period of time (2 hours) or requires storage temperature of -20 degrees C. Does anyone have any experience or recommendations with these types of kits? 

Thank you!

8 Replies

We use the Vidan Diagnostics LucidPlus device to test for beta hydroxybutyrate. It is waived, and the reagent and controls are room temperature. We have not had any issues with it.

Do you have to specifically have Betahydroxybutyrate or is a ketone test acceptable?  Many POC systems have waived ketone testing capability that can do this in seconds, including several of the glucometers currently on market...

Thank you, Kathleen!  That sounds promising! Unfortunately, yes. The clinic is looking specifically for BHB...

I attended a presentation by Dr Dennis Begos, the Senior Medical Director at Nova, and learned a lot about this topic. Thought I'd share some info on BHB. Thankful for the annual meetings our Northwest Point of Care Group puts on; there are always lots of great speakers that increase my knowledge of our field.

I knew we were getting tons of negatives on our ER DKA patients and in years past have fielded several calls from ER docs asking if our test detected BHB, which it does not. (okay, maybe not TONS, but enough to catch my attention and do some basic research years ago)

Turns out, in the UK >75% of hospitals use POCT BHB. It's a shame we haven't caught on in the US yet. I want to pursue this for our facility, but it will require education. Studies have shown decreased time to resolution of DKA monitoring BHB vs Acetoacetate. Almost 12 hours faster treatment times. Patients with euglycemic DKA (becoming more common with increased numbers of patients on SGLT-2 inhibitors) especially require monitoring with BHB; our standard ketone won't detect BHB and will often give a negative, but the patient's BHB will be elevated. BHB comprises up to 80% of the ketones produced by our bodies. 

And thank you, Kathleen!!! I'm going to be researching that kit. This had fallen back a ways on my to-do list and is moving back up thanks to this new lead on a waived device.

The Abbott Freestyle Precision Pro glucometer measures BHB. I am unsure if Abbott is still supporting that meter but we used them in all of our pediatric diabetes clinics for BHB even though we used the Nova meters for glucose.

We use the Abbott Freestyle Precision Pro in our Endo clinics also.  Yes, Abbott is still supporting them.  We also use Nova for our glucose monitoring, and added the Freestyle a few years ago for the ketone need.  It's interfaced with our QML to streamline things.

We also use the Abbott Freestyle Precision Pro in our Peds Endo clinic and are getting ready to add it to our Inpatient Pediatric and Emergency Room specifically for DKA patients.  Currently for ER, they send a blood sample down for a serum acetone and just get a pos/neg result, so this is going to be a big improvement.

We used STAT-Site WB by EKF in the lab, but it is a waived POC test. Results within 5-10 seconds, strips and reagents are stored at room temperature, and very easy to use (similar to glucose meter). 

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Kayla Cooper
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