POC CBC instrument

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Does anyone recommend a moderately complex CBC (3-part or 5-part) instrument that is low-maintenance? We are looking for our special pathogens lab. The device will not be used often, beyond regular QC and proficiency testing, hence low maintenance.

9 Replies

Jake Fray

Tue Nov 18, 2025 at 10:31AM

I use the Sysmex Poch-100i which has a CBC and 3 part diff. Neutrophils, lymphocytes, and then a "mixed" field for other granulocytes and immature cells. We use this in our High Risk (special pathogens) laboratory here at DH. We don't report the "mixed" as our medical director didn't approve validation, but it works well and uses two reagents; a lysing reagent and diluent. Has three levels of quality control. I've been using for over 8 years and like it. Happy to discuss in more detail if you'd like Jacob.Fray@dhha.org

Beth Ann VanOrder

Tue Nov 18, 2025 at 10:33AM

I would recommend the Coulter DXH520. I worked at a moderately complex lab using this instrument for around 3 years. It does perform a 5 part diff. Very user friendly and very reliable. We didn't even keep a service contract on these instruments throughout our entire system and I never needed to call for maintenance. QC was very reliable, never had to order additional QC for troubleshooting or QC outages. Only three reagents and very minimal maintenance. If I recall daily maintenance was running a startup, QC, and shutdown. Monthly was a bleach cycle and filter clean. Calibration every six months which was always straightforward and lubricating some pistons annually. There was no need to have a service rep do the annual PM, I did that myself.

Carol Jarosik

Tue Nov 18, 2025 at 11:08AM

I just finished validating the PixCell HemoScreen for one of our UCCs. It's a neat little analyzer with almost no maintenance. Do a shutdown/startup weekly and change a filter every 6 months, that's it. It performs a CBC with 5 part diff in a cartridge. No reagents required; all reagents are in the cartridge. Cartridges are stored at room temp; QC is refrigerated. Samples can be either fingerstick or venipuncture.

Nita Hospel

Tue Nov 18, 2025 at 11:55AM

For what you are looking for I also like the PixCell HemoScreen. As a distribution rep, we work with a lot of Vendors and this is indeed a slick unit.

HemoScreen+Brochure.pdf

Autilia Sisti

Tue Nov 18, 2025 at 12:53PM

Thank you all- as always this is great information from a great group of people!

Liesel Nelson

Tue Nov 18, 2025 at 12:57PM

For a special pathogens case, I do like the cartridge-based testing of the PixCell. Post-testing decontamination much more straightforward. Testing is expensive per test, but sounds like volumes will be low. Have fun!

Leo Beggs

Tue Nov 18, 2025 at 6:22PM

I work for PixCell as a Clinical Applications Specialist, but I do like the HemoScreen it a lot for a special pathogens/biocontainment use-case. I worked at Johns Hopkins in their Biocontainment Unit for a few years and used the poch-100i. I think the HemoScreen is a lot better compared to it since it has less maintenance and reagents to keep track of.

Kristy Saunders

Wed Dec 10, 2025 at 4:14PM

Hi! We utilize the Sysmex XN-450 (5-part diff) platform in our freestanding emergency departments. The operations are very easy, maintenance is extremely low and the instrument is very reliable. We purchased 6 initially in 2017 and now have 9 instruments. QC- is based on your accreditation guidelines and policies but we perform 3 levels of QC every 24hrs. We have BCQM (beyond care quality monitoring) to manage our QC and able to remotely which has been a huge plus since
we are geographically spread out.

Jim Yakimec

Fri Jan 02, 2026 at 1:47PM

hi. Like Kristy, we purchased a Sysmex XN 430 (like the 450 less the reticulocytes) to replace the Sysmex pocHi. I'm just waiting for LIS for the past 2 yrs to interface it, it will go through data innovations with auto commenting and interpretive comments as applicable.
BCQM and Insight QC (remote real time QC monitoring), are more reliable than the pocHi, sysmex service rep calibrated, 6 part diff). Looking forward when it's finally interfaced.

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POC CBC instrument